职称：教授
职务：副所长
系所：纳米化学与生物学研究所
办公室：校本部E楼201室
电话：021-66135277-102
Email: ancao@shu.edu.cn
个人简介
上海大学纳米化学与生物学研究所，教授，博士生导师：ChemMedChem国际顶问编委。主要从事纳米材料生物功能设计、纳米材料与蛋白质相互作用机制研究、新型纳米显像试剂及多功能靶向纳米药物研究。作为负责人先后承担国家自然科学基金6项和科技部863项目4项，承担国家重点研发计划纳米科技重点专项课题1项：并参与多项国家自然科学基金委重大研究计划课题、重大项目课题和科技部973课题的研究工作。已发表SCl论文80余篇，获国家发明专利10项。部分工作被NPG Asia-Mater、Nature China、F1000Pime等推荐评述，一篇论文入选为全国2011年百篇最有影响的国际论文。2015年获上海市自然科学等奖(排名第3)，2018年获国家自然科学二等奖(排名第3)。
学术经历
1985-1989 浙江大学，化学系，理学学士
1992-1995 浙江大学，材料系，工学硕士
1995-1998 北京大学，化学与分子工程学院，理学博士
1998-2000 美国康奈尔大学，化学与化学生物学系博士后
2000-2008 北京大学，化学与分子工程学院讲师、副教授
2004年 日本大阪大学，蛋白质研究所，客座副教授
2008年至今 上海大学，纳米化学与生物学研究所，教授
研究方向
基于结构的纳米材料生物功理性设计：人工蛋白质（抗体、酶等）设计
纳米生物医学：多功能靶向纳米药物、纳米显像与诊断
纳米材料与生物大分子相互作用作用机制
代表成果
1. L Li, W-S Xi, Q Su, Y Li, G-H Yan, Y Liu, H Wang, A Cao*. Unexpected size effect: the interplay
between different-sized nanoparticles in their cellular uptake. Small(2019), 1901687.
2. G-H Yan, K Wang. Z Shao, L Luo, Z-M Song. J Chen, R Jin, X Deng. H Wang*, Z Cao, Y Liu, A Cao*. Artificial antibody created by conformational reconstruction of the complementary-determining region on gold nanoparticle.PNAS (2018),115(1),E34-43.
3. Y Cao, Y Cui, Y Yang. J Hua, Z-M Song .H Wang. Y Liu, A Cao*. Silica nanoparticle with a single His-tag for addressable functionalization, reversible assembly, and recycling. Nano Research 2018.115:2512-2522.
4.Y Liu, ZM Song. X Deng. Y Cui, YF Yang. K Han, R Jin, H Wang*, Y Liu, A Cao*. Chitosan-coated red fluorescent protein nanoparticle as a potential dual-functional siRNA carrier. Nanomedicine (Zond.) (2015).10(13).2005-2016.
5. ST Yang. Y Liu, Y Wang. A Cao*. Biosafety and bioapplication of nanomaterials by designing
protein-nanoparticle interactions. Small(2013),9,1635-53.
6. Y Yang. K Xiang. YX Yang. YW Wang. X Zhang. Y Cui, H Wang*, QQ Zhu, L Fan, Y Liu and A Cao*. Individually-coated near-infrared fluorescent protein as a safe and robust nanoprobe for in vivo imaging. Nanoscale (2013),5,10345-10352.
7. X Yang. Z Cai, Z Ye, S Chen, Y Yang. H Wang*, Y Liu, A Cao*. In situ synthesis of porous silica nanoparticles for covalent immobilization of enzymes. Nanoscale(2012).4,414-416.
8. Y Chang.ST Yang. J Liu, E Dong. Y Wang. A Cao*, Y Liu, H Wang*. In vitro toxicity evaluation of graphene oxide on A549 cells. Toxico Lett (2011).200,201-210.
9.A Cao*, Z Ye, Z Cai, E Dong. X Yang. G Liu, X Deng. Y Wang. ST Yang. H Wang*, M Wu, Y Liu. A facile method to encapsulate proteins in silica nanoparticles: Encapsulated green fluorescence protein as a robust fluorescence probe. Angew Chem Int Ed(2010), 49, 3022-3025.
10. A Cao*, Z Liu, S Chu, M Wu, Z Ye, Z Cai, Y Chang. S Wang*, Q Gong. Y Liu*. A facile one-step method to produce graphene-CdS quantum dots nanocomposite as a promising optoelectronic material. Adv Mater (2010),22,103-106.
科研项目
国家自然科学基金项目：在研2项(Nos.31571024,31871007)
国家重点研发计划纳米科技重点专项课题：在研1项(No.2016YFA0201600)
获奖情况
2018:国家自然科学二等奖一项（排名第3）
2015:上海市自然科学等奖一项（排名第3）
教授课程
《化学前沿进展与机遇》（本科生通识课）
《高等仪器分析》（硕士生专业课）
Aoneng Cao
Professor
Institute of Nanochemistry and Nanobiology
Room 201, Building E
66135277-102(TEL)
66135275(FAX)
ancao@shu.edu.cn
Educational Background
1985-1989 B. Sc, Department of Chemistry, Zhejiang University
1992-1995 M. Sc, Department of Material Science, Zhejiang University
1995-1998 Ph.D, College of Chemistry and Molecular Engineering, Peking University
Academic Background:
1998-2000 Postdoc, Department of Chemistry and Chemical Biology, Cornell University, USA
2000-2002 Lecturer, College of Chemistry and Molecular Engineering, Peking University
2002-2008 Associate Professor, College of Chemistry and Molecular Engineering. Peking
University
2004 Visiting associate Professor, Institute for Protein Research, Osaka University, Japan
2008- Professor, Institute of Nanochemistry and Nanobiology, Shanghai University
Research Field:
Multi-functional Nanomaterials for Targeted Drug-delivery
Mechanism of the Interaction between Nanomaterials and Biomolecules
Structural and Functional Design of Nanomaterials: artificial proteins (antibodies, enzymes,…)
Selected Publications
1. L Li, W-S Xi, Q Su, Y Li, G-H Yan, Y Liu, H Wang, A Cao*. Unexpected size effect: the interplay
between different-sized nanoparticles in their cellular uptake. Small(2019), 1901687.
2. G-H Yan, K Wang. Z Shao, L Luo, Z-M Song. J Chen, R Jin, X Deng. H Wang*, Z Cao, Y Liu, A Cao*. Artificial antibody created by conformational reconstruction of the complementary-determining region on gold nanoparticle.PNAS (2018),115(1),E34-43.
3. Y Cao, Y Cui, Y Yang. J Hua, Z-M Song .H Wang. Y Liu, A Cao*. Silica nanoparticle with a single His-tag for addressable functionalization, reversible assembly, and recycling. Nano Research 2018.115:2512-2522.
4.Y Liu, ZM Song. X Deng. Y Cui, YF Yang. K Han, R Jin, H Wang*, Y Liu, A Cao*. Chitosan-coated red fluorescent protein nanoparticle as a potential dual-functional siRNA carrier. Nanomedicine (Zond.) (2015).10(13).2005-2016.
5. ST Yang. Y Liu, Y Wang. A Cao*. Biosafety and bioapplication of nanomaterials by designing
protein-nanoparticle interactions. Small(2013),9,1635-53.
6. Y Yang. K Xiang. YX Yang. YW Wang. X Zhang. Y Cui, H Wang*, QQ Zhu, L Fan, Y Liu and A Cao*. Individually-coated near-infrared fluorescent protein as a safe and robust nanoprobe for in vivo imaging. Nanoscale (2013),5,10345-10352.
7. X Yang. Z Cai, Z Ye, S Chen, Y Yang. H Wang*, Y Liu, A Cao*. In situ synthesis of porous silica nanoparticles for covalent immobilization of enzymes. Nanoscale (2012).4,414-416.
8. Y Chang.ST Yang. J Liu, E Dong. Y Wang. A Cao*, Y Liu, H Wang*. In vitro toxicity evaluation of graphene oxide on A549 cells. Toxico Lett (2011).200,201-210.
9.A Cao*, Z Ye, Z Cai, E Dong. X Yang. G Liu, X Deng. Y Wang. ST Yang. H Wang*, M Wu, Y Liu. A facile method to encapsulate proteins in silica nanoparticles: Encapsulated green fluorescence protein as a robust fluorescence probe. Angew Chem Int Ed (2010), 49, 3022-3025.
10. A Cao*, Z Liu, S Chu, M Wu, Z Ye, Z Cai, Y Chang. S Wang*, Q Gong. Y Liu*. A facile one-step method to produce graphene-CdS quantum dots nanocomposite as a promising optoelectronic material. Adv Mater (2010),22,103-106.
Research Projects:
1. Kinetic study of the interaction between proteins and bio-nanomaterials, National Natural Science Foundation of China (Grant No.31571024),2016,01-2019,12
2. Structural mechanism and anti-cancer activity of the anti-EGFR Goldbody, National Natural Science Foundation of China (Grant No.31871007),2019,01-2022,12
3. National Key Research and Development Program (No.2016YFA0201602),2016,06-2021,05
Honors and Awards:
National Natural Science Award (Second Class) in 2018
Shanghai Natural Science Award (First Class) in 2015
Courses:
Chemistry for Everyone (for Undergraduates)
Advanced Instrumental Analysis (for Graduate Students)