<p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 31.5pt; mso-char-indent-count: 3.0"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">近日，上海大学环化学院王艳丽教授课题组在国际顶尖期刊《</span><span lang="EN-US" style="FONT-FAMILY:  微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Advanced Materials</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》（先进材料，影响因子：</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">21.95</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">）上发表题为《</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》的研究论文。并被编辑部邀请作为</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Video Abstracts</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">（视频摘要）放在首页展览。</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">《</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Advanced Materials</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》是材料与化学大领域的顶尖期刊。在国际材料领域科研界上享誉盛名！</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">该论文是上海大学， 上海海军军医大学，美国哈佛大学，新加坡国立大学共同合作完成的，上海大学为第一通讯单位。</span></font></p>
<p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 31.5pt; mso-char-indent-count: 3.0"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman""></span></font><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">王艳丽教授课题组报道了"一种新型基于细胞膜通透性的高效肿瘤细胞核靶向荧光纳米探针"。长期以来，有效的肿瘤靶向一直是临床上的一大挑战。传统的基于实体瘤高通透性和滞留效应 </span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">(EPR)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">的靶向方法只有大约</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">5%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">的靶向率。为了解决这一问题，一种基于石墨烯的肿瘤细胞核靶向荧光纳米探针<span lang="EN-US">(</span></span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Graphene-based tumor cell nuclear targeting fluorescent nanoprobe , GTTN)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">被开发出来，具有全新的肿瘤靶向机制。</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">GTTN</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">是一种石墨烯<span lang="EN-US">-</span>单晶结构的两亲性荧光探针。该探针具有肿瘤细胞特异性靶向的特点，它通过肿瘤细胞膜高于正常细胞膜的通透性，直接穿过肿瘤细胞膜，并特异性靶向肿瘤细胞核。王艳丽教授将这种新的靶向机制命名为细胞膜通透性靶向</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">(Cell membrane permeability targeting mechanism (CMPT)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">机</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">制，这与</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">EPR</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">效应有很大的不同。这些探针可以在肿瘤早期识别肿瘤组织，并在单细胞水平上跟踪肿瘤细胞的侵袭转移情况。更重要的是，肿瘤靶向率从不足</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">5%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">提高到</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">50%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">以上。这一高效、精准的肿瘤细胞核靶向技术的实现将加速肿瘤诊疗新时代的到来。这一成果的后续研究及临床转化将会在上海大学加大力度提升医学学科建设的进程中，不断推进，打造产学研医一体化发展的国际一流平台，实现基础研究的高效转化，贡献社会，造福人类。<span lang="EN-US"><o:p></o:p></span></span></font></p>
<p class="MsoNormal" style="TEXT-ALIGN: left; MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 36pt; mso-pagination: widow-orphan" align="left"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">王艳丽教授是上海大学一手培养起来的优秀学生、青年教师，她带领团队，攻坚科学难题，也体现了上大人的精神和上大创新人才培养模式的成功。立足于本职工作，刻苦努力，踏实进取，校荣我荣，我为上大是努力奋斗、勇争一流的上大人的精神体现。 </span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><o:p></o:p></span></font></p>
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<pre style="LINE-HEIGHT: 150%"><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%">论文链接： <span lang="EN-US"><a href="https://doi.org/10.1002/adma.201807456"><font color="#0563c1">https://doi.org/10.1002/adma.201807456</font></a></span></span></pre>
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