职称：副研究员、硕导

系所：有机复合污染研究中心

办公室：校本部东区环化楼

E-mail：sunhaoyu2021@shu.edu.cn

个人简介

孙昊宇，中共党员，长期从事新污染物hormesis（毒物兴奋）效应与机制，新污染物联合暴露效应及风险评价。先后承担国家自然科学基金面上项目、国家重点研发计划重点专项子课题、国家自然科学基金青年项目、博士后基金面上项目等，先后入选博士后创新人才支持计划、上海市“超级博士后”激励计划。目前发表学术论文70余篇，其中以第一作者及通讯作者在环境领域专业期刊上发表SCI论文30余篇，EI及中文核心论文8篇；参与撰写专著《环境化学前沿》（书章节）1章。课题组学生多人次获国家奖学金等荣誉。

学术经历

2021.07 - 至今  副研究员   上海大学   环境与化学工程学院

2019.03 - 2021.07 博士后   同济大学    土木工程学院

2015.09 - 2019.03 博士  同济大学  环境科学与工程学院

2012.09 - 2015.06 硕士  山东大学  环境科学与工程学院

2008.09 - 2012.06 学士  河北科技大学  环境科学与工程学院

研究方向

Hormesis（毒物兴奋）效应与机制

新污染物联合毒性与联合抗性及QSAR模型构建

新污染物与生物大分子的分子间互作表征

机器学习辅助的新污染物环境风险评估

代表成果

1. Intermolecular interactions mediate the stimulatory and inhibitory effects of typical veterinary antibiotics on soil xylanase activity, Applied Soil Ecology, 223 (2026): 107104.

2. Antagonistic effects of typical veterinary antibiotic and herbicide on Cu/Zn superoxide dismutase activity: Competitive binding at the dimer interface, International Journal of Biological Macromolecules, 329 Part 1 (2025): 147805.

3. Data-driven risk assessment of antibiotic mixtures against gram-negative and gram-positive bacteria: QSAR, joint toxic action, and component contribution, Environment International, 202 (2025): 109639.

4. Spontaneous interactions between typical antibiotics and soil enzyme: Insights from multi-spectroscopic approaches, XPS technology, molecular modeling, and joint toxic actions, Journal of Hazardous Materials, 480 (2024): 135990.

5. A new parameter for quantitatively characterizing antibiotic hormesis: QSAR construction and joint toxic action judgment, Journal of Hazardous Materials, 479 (2024): 135767.

6. Acute toxicity of binary mixtures for quorum sensing inhibitors and sulfonamides against Aliivibrio fischeri: QSAR investigations and joint toxic actions, Current Research in Toxicology, 6 (2024): 100172.

7. Hormesis Research in China Is More Prevalent than Previously Thought, Dose-response, 20 (2022): https://doi.org/10.1177/15593258221112650.

8. Hormesis-based cross-phenomenon in judging joint toxic action for mixed pollutants, Current Opinion in Environmental Science & Health, 28 (2022): 100372.

9. A simple judgment method for joint action of antibacterial agents on bacterial resistance, MethodsX, 9 (2022): 101700.

10. The role of energy source or substrate in microbial hormesis, Current Opinion in Toxicology, 29 (2022): 10-18.

11. Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology, Trends in Pharmacological Sciences, 41 (2020): 544-556.

12. Hormetic dose-dependent response about typical antibiotics and their mixtures on plasmid conjugative transfer of Escherichia coli and its relationship with toxic effects on growth, Ecotoxicology and Environmental Safety, 205 (2020): 111300.

13. Regular time-dependent cross-phenomena induced by hormesis: A case study of binary antibacterial mixtures to Aliivibrio fischeri, Ecotoxicology and Environmental Safety, 187 (2020): 109823.

14. A deep insight into the toxic mechanism for sulfonamides based on bacterial cell-cell communication, Environment International, 129 (2019): 185-193.

15. QSAR-based investigation on antibiotics facilitating emergence and dissemination of antibiotic resistance genes: A case study of sulfonamides against mutation and conjugative transfer in Escherichia coli, Environmental Research, 173 (2019): 87-96.

16. Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli, Scientific Reports, 6 (2016): 33718.

17. Toxic effects of chrysoidine on human serum albumin: isothermal titration calorimetry and spectroscopic investigations, Luminescence, 31 (2016): 335-340.

18. Insights into the effect of N-acetyl-L-cysteine-capped CdTe quantum dots on the structure and activity of human serum albumin by spectroscopic techniques, Journal of Luminescence, 167 (2015): 1-7.

19. Effects of N-Acetyl-L-Cysteine-Capped CdTe Quantum Dots on Bovine Serum Albumin and Bovine Hemoglobin: Isothermal Titration Calorimetry and Spectroscopic Investigations, Journal of Biochemical and Molecular Toxicology, 12 (2014): 549-557.

20. Spectroscopic investigations on the effect of N-Acetyl-L-Cysteine-Capped CdTe Quantum Dots on catalase, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 132 (2014): 692-699.

21. Comparison of the binding of the dyes Sudan II and Sudan IV to bovine hemoglobin, Journal of Luminescence, 148 (2014): 143-150.

22. 乙酸钠与抗生素对大肠杆菌时间依赖的hormesis及联合作用判别, 环境科学学报, 46 (2026): 446-454.

23. TBP与LEV混合物对铜绿微囊藻和斜生栅藻的联合毒性效应, 水生态学杂志, 46 (2025): 13-21.

24. 基于细菌群体感应的抗生素联合毒性评估, 中国科学: 技术科学, 54 (2024): 1949-1965.

25. 典型有机磷阻燃剂对蓝藻的Hormesis效应及机制探究, 安全与环境学报, 24 (2024): 809-818.

26. 外加碳源对抗生素诱导大肠杆菌Hormesis效应的调控作用, 生态毒理学报, 18 (2023): 156-164.

27. 纳米银和典型农药对斜生栅藻的联合毒性及机制初探, 安全与环境学报, 23 (2023): 2949-2957.

28. “鸡尾酒”式混合抗生素对细菌耐药性的影响, 中国环境科学, 42 (2022): 434-443.

29.抗生素和纳米银对大肠杆菌耐药性的联合效应, 中国环境科学, 40 (2020): 5045-5054.

科研项目

1. 国家自然科学基金面上项目，2027-01至2030-12，主持

2. 国家重点研发计划重点专项子课题，2023-12至2026-11，主持

3. 国家自然科学基金面上项目，2023-01至2026-12，主持

4. 国家自然科学基金青年项目，2021-01至2023-12，主持

5. 中国博士后创新人才支持计划，2019-04至2021-03，主持

6. 中国博士后基金面上项目，2020-01至2021-12，主持

7. 上海市“超级博士后”激励计划，2019至2020，主持

获奖情况

        2019年同济大学优秀毕业研究生

        2016年博士研究生国家奖学金

        2015年博士研究生国家奖学金

        2014年山东大学优秀毕业研究生

        2014年硕士研究生国家奖学金

        2014年山东大学优秀共青团员